Stepped Care for Depression in Heart Failure

Completed · Not applicable

Conditions studied: Heart Failure, Depressive Disorder, Major

In brief

This study evaluates stepped care for depression in patients with heart failure (HF). The stepped care intervention consists of individualized cognitive behavior therapy (CBT). Half of the participants will receive stepped care and half will receive usual care for depression; all participants will receive heart failure self-care education and support. The primary aims are to determine whether stepped care is superior to usual care for depression, and whether treating depression improves heart failure self-care outcomes.

Key facts

Study ID: NCT02997865
Run by: Washington University School of Medicine
People needed: 139
Starts: 2017-02-17
Expected to finish: 2021-12-31
Last updated by the study team: 2023-02-10

Who can join

Age: 25 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Stable, clinically-documented New York Heart Association (NYHA) Class I-III heart failure.
Current major depressive episode.
Baseline Beck Depression Inventory (BDI-II) score 14 or greater

You may not qualify if…

Dementia or other significant cognitive or communication deficits
Terminal illness other than HF
Insurmountable logistical barriers to participation
Age less than 25 years
Current clinically significant substance abuse, bipolar disorder, schizophrenia, or other psychotic disorder
High risk of suicide
Current participation in non-study psychotherapy for depression or other psychiatric conditions
Initiation or modification of antidepressant medication treatment within past two months
Renal or hepatic conditions that would preclude the use of antidepressants.

Where it is running

Behavioral Medicine Center Washington University — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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