Shift Work, Heredity, Insulin, and Food Timing Study

Completed

Conditions studied: Shift Work Type Circadian Rhythm Sleep Disorder, Diabetes Mellitus, Type 2, Circadian Rhythm Sleep Disorder, Shift Work Type, Insulin Resistance

In brief

The purpose of this study is to determine whether night time eating that coincides with elevated endogenous melatonin impairs glucose tolerance, particularly in carriers of the MTNR1B risk allele.

Key facts

Study ID

NCT02997319

Run by

Massachusetts General Hospital

People needed

365

Starts

2017-02-24

Expected to finish

2021-05-08

Last updated by the study team

2021-05-19

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Male or non-pregnant female
• 18-60 years
• Currently employed (night shift workers and day workers), graduate students, part-time workers, or unemployed
• Able and willing to give consent relevant to genetic investigation

You may not qualify if…

• Currently taking any medications for the treatment of diabetes
• Currently taking medications known to affect glycemic parameters, such as glucocorticoids, growth hormone or fluoroquinolones
• Pregnant, nursing or at risk of becoming pregnant
• Chronic renal failure, hepatic diseases, or cancer diagnoses
• Bulimia diagnosis, prone to binge eating
• Eating disorder diagnosis such as anorexia, binge eating, or bulimia
• With psychiatric illness, such as schizophrenia or bipolar affective disorder
• Blind
• History of bariatric surgery

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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