Ivacaftor for Acquired CFTR Dysfunction in Chronic Rhinosinusitis (EDSPD Protocol)

Running, not enrolling

Conditions studied: CRS

In brief

The purpose of this study is to establish the novel endoscopically-directed sinus potential difference (EDSPD) assay as an endpoint for therapy of sinus disease.

Key facts

Study ID

NCT02997020

Run by

University of Alabama at Birmingham

People needed

30

Starts

2017-05-18

Expected to finish

2027-05-01

Last updated by the study team

2026-04-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age > 18 years
• Able to give consent
• A diagnosis of CRS, as determined by the Sinus and Allergy Health Partnership criteria
• Has cultured out at least one gram negative bacteria (e.g. Pseudomonas aeruginosa, Escherichia coli, Stenotrophomonas maltophila) within the previous month
• Is scheduled for either routine endoscopic surgery or has previously undergone endoscopic surgery and presents to clinic for routine endoscopic evaluation

You may not qualify if…

• Age < 18 years
• Unable to give consent
• Active diagnosis of cancer, autoimmune disease, or any know immunodeficiency
• Women who are pregnant or breastfeeding

Where it is running

• University of Alabama at Birmingham — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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