Stand up to Cancer: MAGENTA (Making Genetic Testing Accessible)
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Conditions studied: BARD1 Gene Mutation, BRCA1 Gene Mutation, BRCA2 Gene Mutation, BRIP1 Gene Mutation, Estrogen Receptor Negative, HER2/Neu Negative, MLH1 Gene Mutation, MSH2 Gene Mutation, MSH6 Gene Mutation, PALB2 Gene Mutation, PMS2 Gene Mutation, Progesterone Receptor Negative, RAD51C Gene Mutation, RAD51D Gene Mutation, Triple-Negative Breast Carcinoma
In brief
This randomized clinical trial studies how well online genetics educational video with or without pre- and/or post-telephone genetics counseling works in assessing cancer-risk distress in patients with triple negative breast cancer. Online genetic education and telephone genetic counseling may help the doctors learn the stress a person feels about their risk of cancer.
Key facts
- Study ID
- NCT02993068
- Run by
- M.D. Anderson Cancer Center
- People needed
- 5200
- Starts
- 2017-04-18
- Expected to finish
- 2026-04-18
- Last updated by the study team
- 2026-02-19
Who can join
Age: 30 and older. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Age 30 or older. Note: Participants must meet each of Criteria 1-4.
- Have access to a healthcare provider and be willing to share genetic results with that provider
- Have at least one ovary
- Have a valid United States mailing address for receipt of saliva kit
- Participants must meet any one of the following 6 criteria:
- Diagnosed with breast cancer at age 45 or younger
- Diagnosed with triple negative (negative for estrogen receptor, progesterone receptor and not human epidermal growth factor receptor 2 [Her2] amplified) breast cancer at 60 or younger
- Have one blood relative with a mutation in BRCA1, BRCA2, BRIP1, PALB2, RAD51C, RAD51D, BARD1, MSH2, MSH6, MLH1, or PMS2
- Have one relative with ovarian cancer
- Have at least 2 relatives with breast cancer on the same side of the family, one of which is =< 50 years of age
- Have one male relative with breast cancer
You may not qualify if…
- Personal history of ovarian cancer
- Unable to read, speak, and understand English
- Unable to provide informed consent
- Unwilling to complete baseline and follow-up questionnaires
- Unable to access the internet
- Previous genetic testing or counseling regarding cancer risk
- Previous bone marrow transplant
- Previous blood transfusion (7 days prior to genetic testing)
- Active hematologic malignancy (cancer that begins in blood-forming tissue, such as leukemia or lymphoma)
Where it is running
- M D Anderson Cancer Center — Houston, Texas, United States
- University of Washington Medical Center — Seattle, Washington, United States
Full record on ClinicalTrials.gov
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