Tranexamic Acid Use and Blood Loss in Total Hip Arthroplasty

Completed

Conditions studied: Tranexamic Acid Use, Blood Loss

In brief

The purpose of this study is to determine the need for a blood transfusion during surgery and to evaluate the levels of certain proteins in the blood when given tranexamic acid.

Key facts

Study ID

NCT02989155

Run by

Ohio State University

People needed

576

Starts

2016-01-01

Expected to finish

2016-12-01

Last updated by the study team

2017-01-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients 18 years of age and older
• Surgical patients who underwent primary total hip arthroplasty (THA)
• Surgical patients who underwent revision THA
• Preoperative hemoglobin values (N) 11 g/dl
• Normal international normalized ratio (INR), prothrombin time (PT), partial thromboplastin time (PTT) values

You may not qualify if…

• - Allergy to tranexamic acid
• Bilateral THA
• History of ischemic heart disease
• Severe chronic heart failure
• Hepatic dysfunction
• Chronic renal failure
• On hemodialysis
• Cerebral infarction
• History of seizure
• Bleeding disorder
• Anticoagulant or aspirin-like medication and long acting NSAID medication
• Short acting NSAID's were discontinued at least 24 hrs before surgery

Where it is running

• The Ohio State University Wexner Medical Center — Columbus, Ohio, United States

Full record on ClinicalTrials.gov

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