[11C]Acetate PET in Patients With Glioma
Stopped early · Not applicable
Conditions studied: Glioma
In brief
At each point that the patient will have \[11C\]-Acetate PET study, this will be compared with standard clinical MR imaging. Abbreviations: XRT - radiation therapy; TMZ - temozolomide (chemotherapy) Quantitative Image Data Analysis: The \[11C\]-Acetate uptake in tumor sites from images will be analyzed qualitatively by visual assessment, quantitatively using a standard uptake value (SUV) in the tumor relative to the contralateral normal brain, and the parameters obtained by compartmental modeling of dynamic data.
Key facts
- Study ID
- NCT02986815
- Run by
- University of Texas Southwestern Medical Center
- People needed
- 5
- Starts
- 2017-01-24
- Expected to finish
- 2020-05-05
- Last updated by the study team
- 2021-03-25
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Male or female, age 18 and older, of any ethnic group
- Spanish-speaking patients will be eligible
- Histological diagnosis of glioma or
- Brain MR imaging suggestive of a glioma or 2HG > 2mM by MR spectroscopy in patients who have not had a surgical procedure to establish the diagnosis.
- Karnofsky Performance status > 70%
- Negative serum pregnancy test or child bearing potential terminated by surgery, radiation, menopause or current use of two approved methods of birth control
- Patient able and willing to provide informed consent
You may not qualify if…
- Patient or legal parent/guardian unable to provide informed consent
- Psychiatric or addictive disorders that preclude obtaining informed consent
- Karnofsky Performance status < 70%
- NYHA class III and IV congestive heart failure
- Unstable angina
- Pregnant or lactating women
- Women of childbearing potential who refuse a pregnancy test
Where it is running
- University of Texas Southwestern Medical Center — Dallas, Texas, United States
Full record on ClinicalTrials.gov
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