The Effects of Hyperbaric Oxygen on Rheumatoid Arthritis

Completed · Not applicable

Conditions studied: RheumatoId Arthritis

In brief

The purpose of this investigation is to determine the effects and ease of using hyperbaric oxygen therapy HBO2 for the treatment of rheumatoid arthritis joint pain and prevention of disease progression. In this study it is our intention to not only evaluate effects and ease of treatment but time, cost, possible adverse events and effect size in an attempt to predict an appropriate sample size and improve on the study design prior to a more extensive study.

Key facts

Study ID

NCT02984943

Run by

David Grant U.S. Air Force Medical Center

People needed

14

Starts

2017-01-19

Expected to finish

2019-04-10

Last updated by the study team

2020-03-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18
• Active duty or Department of Defense (DoD) beneficiary
• Diagnosed with rheumatoid arthritis meeting ACR/EULAR 2010 classification criteria and any one of the following:
• Patient does not want to be on rheumatologic medications
• Patient has contraindications to standard rheumatologic medications
• Patient has failed treatment or an incomplete response with standard rheumatologic medications
• Women of childbearing age must have a negative pregnancy test and currently be on a reliable form of birth control

You may not qualify if…

• Severe depression
• Dementia, mental disability
• Claustrophobia
• Uncontrolled seizure disorder
• Uncontrolled asthma/severe chronic obstructive pulmonary disease (COPD) with partial pressure of carbon dioxide (pCO2) > 45 mmHg on arterial blood gas
• Grade 4 congestive heart failure
• Unstable angina
• Chronic/acute otitis media/sinusitis
• Major tympanic membrane trauma
• Severe kyphoscoliosis
• Prior chemotherapy with Bleomycin and evidence of deterioration in diffusion capacity of the lung for carbon monoxide (DLCO) after a single hyperbaric oxygen exposure
• History of renal insufficiency or glomerular filtration rate (GFR)< 30
• Women that are currently pregnant or breast feeding or intend on becoming pregnant while enrolled in the study

Where it is running

• David Grant Medical Center — Travis Air Force Base, California, United States

Full record on ClinicalTrials.gov

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