Incidence of Residual Neuromuscular Blockade in Intra-abdominal Surgery: A Prospective, Observational Study
Completed
Conditions studied: Neuromuscular Blockade, Pulmonary Complication
In brief
The aim of this prospective, observational study is to determine the incidence of post-operative residual neuromuscular blockade (PRNB) in patients undergoing intra-abdominal procedures compared to patients undergoing other noncardiac/non intra-thoracic procedures that also require non-depolarizing neuromuscular blocking agents (NMBA) administration. As intra-abdominal surgeries are independently associated with post-operative pulmonary complications (PPCs), it is important to highlight other factors, such as PRNB, that could contribute to these complications.Although it has been shown that the risk of adverse respiratory events can be reduced by intra-operative quantitative neuromuscular monitoring, such monitoring is not in widespread use.This study will incorporate quantitative monitoring in the post-anesthesia care unit (PACU) setting by using the Stimpod NMS450® in an effort to show a disparity in the incidence of residual paralysis between these two patient populations and to emphasize the need to implement more accurate neuromuscular monitoring, especially for those that are already at increased risk for respiratory complications.
Key facts
- Study ID
- NCT02984839
- Run by
- OhioHealth
- People needed
- 120
- Starts
- 2016-11-01
- Expected to finish
- 2017-05-16
- Last updated by the study team
- 2018-07-26
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- English speaking
- ASA physical status classification I-IV
- Procedures requiring intubation and nondepolarizing NMBA administration
- Laparoscopic surgery
- Intra-abdominal surgery
- Procedures using the Da Vinci surgical system
- Tonsillectomy
- Septoplasty
- Shoulder surgery
- Total hip arthroplasty
- Carotid endarterectomy
- Cervical spine surgery
- Parotidectomy
- Thyroidectomy
- Aorto-bifemoral bypass
- Micro laryngoscopy
- Nasal or sinus surgery
- Dental extraction
You may not qualify if…
- Non-English speaking population
- ASA V and VI
- Unable to give informed consent
- Cardiac or intra-thoracic procedures performed
- Severe renal insufficiency (Serum Creatinine >2.0 mg/dL)
- Severe hepatic dysfunction
- Underlying neuromuscular disease
- Currently enrolled in another therapeutic study
- Pregnant patients at any stage of pregnancy
Where it is running
- OhioHealth Doctors Hospital — Columbus, Ohio, United States
Full record on ClinicalTrials.gov
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