Communication During Hospitalization About Resuscitation Trial

Completed · Phase 2/Phase 3

Conditions studied: Severe Life-limiting COPD, Severe Life-limiting Heart Failure, Severe Life-limiting Cirrhosis, Severe Life-limiting Malignancy, Severe Functional Impairment, End Stage Renal Disease

In brief

This multicenter RCT of 200 hospitalized patients and their family members evaluates an "informed assent" approach to discussing cardiopulmonary resuscitation, compared to usual care, in older seriously ill hospitalized patients with severe life-limiting illness or severe functional impairment.

Key facts

Study ID

NCT02984124

Run by

University of Vermont

People needed

182

Starts

2016-12-01

Expected to finish

2025-12-01

Last updated by the study team

2026-05-29

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• >65 years old
• English speaking
• Must have one or more of the following:
• Chronic life-limiting illness with median survival <2 years defined as: 1) metastatic cancer or inoperable lung cancer; 2) COPD requiring oxygen; 3) New York Heart Association Class III or IV heart failure, 4) Child's Class C cirrhosis or MELD score of >20, 5) End-stage renal disease (must be on dialysis and ≥ 75 years old), 6) Advanced pulmonary fibrosis/interstitial lung disease, 7) Advanced pulmonary hypertension
• Severe functional impairment defined as dependence with >4 activities of daily living (ADLs) on Katz Index of Independence in ADLs.

You may not qualify if…

• Has already definitively chosen DNR status
• Unable to provide informed consent
• Refused consent
• Currently listed on a transplant list (awaiting transplant)
• Inappropriate for study enrollment per clinician
• Known to have a left ventricular assist device (LVAD)
• Research team unavailable
• Patient discharged from hospital prior to enrollment

Where it is running

• University of North Carolina — Chapel Hill, North Carolina, United States
• Medical University of South Carolina — Charleston, South Carolina, United States
• University of Vermont — Burlington, Vermont, United States
• University of Washington — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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