Impact of CPAP Level on V/Q Mismatch in Premature Infants
Completed · Not applicable
Conditions studied: Infant, Premature, Diseases, Respiratory Insufficiency Syndrome of Newborn
In brief
Continuous positive airway pressure (CPAP) is used in premature infants to maintain lungs open and facilitate gas exchange. When ventilation/perfusion (V/Q) mismatch is present, areas of the lung that are open for gas exchange do not match up with the areas of the lung that are receiving blood for gas exchange. This study measure the responsiveness of V/Q mismatch to changes in the amount (or level) of CPAP.
Key facts
- Study ID
- NCT02983825
- Run by
- Children's Hospital of Philadelphia
- People needed
- 21
- Starts
- 2017-02-01
- Expected to finish
- 2020-02-13
- Last updated by the study team
- 2021-03-25
Who can join
Age: 0 and older, up to 1. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Born at 27-35 weeks gestational age (GA) by best obstetric estimate, determined by the clinical obstetric team during antepartum admission.
- Age limits: 24 hours of age - 35 weeks corrected gestational age.
- On continuous CPAP support between 4-8 cm H2O for greater than 24 hours, as document on the bedside infant flow sheet.
- Supplemental oxygen requirement, with a fraction of inspired oxygen (FiO2) 0.25 for at least 2 consecutive hours, as documented on the bedside infant flow sheet.
You may not qualify if…
- Congenital anomalies, as determined by the clinical supervising physician.
- Current or prior air leak syndrome, as determined by the clinical supervising physician.
Where it is running
- Hospital of the University of Pennsylvania — Philadelphia, Pennsylvania, United States
- The Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States
- Pennsylvania Hosptital — Philadelphia, Pennsylvania, United States
Full record on ClinicalTrials.gov
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