Myocardial Ischemia and Transfusion

Completed · Phase 3

Conditions studied: Myocardial Infarction, Anemia

In brief

The purpose of this study is to compare two red blood cell transfusion strategies (liberal and restrictive) for patients who have had an acute myocardial infarction and are anemic.

Key facts

Study ID

NCT02981407

Run by

Rutgers, The State University of New Jersey

People needed

3506

Starts

2017-04-25

Expected to finish

2023-10-20

Last updated by the study team

2024-05-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18 years of age or older
• Either ST segment elevation myocardial infarction or Non ST segment elevation myocardial infarction consistent with the 3rd Universal Definition of Myocardial Infarction criteria that occurs on admission or during the index hospitalization
• Hemoglobin concentration less than 10 g/dL at the time of random allocation
• Patient physician believes that both of the transfusion strategies are consistent with good medical care for the patient

You may not qualify if…

• Uncontrolled acute bleeding at the time of randomization defined as the need for uncrossed or non-type specific blood
• Decline blood transfusion
• Scheduled for cardiac surgery during the current admission
• Receiving only palliative treatment
• Known that follow-up will not be possible at 30 days
• Previously participated in MINT
• Currently enrolled in a competing study that interferes with the intervention or follow-up of MINT or enrolled in a competing study that has not been approved by the local Institutional Review Board
• Patient physician does not believe the patient is an appropriate candidate for the trial

Where it is running

• University of Arkansas Medical Sciences (UAMS) Hospital — Little Rock, Arkansas, United States
• VAGLAHS — Los Angeles, California, United States
• Danbury Hospital — Danbury, Connecticut, United States
• Rush University Medical Center — Chicago, Illinois, United States
• University of Chicago Medical Center — Chicago, Illinois, United States
• Alexian Brothers Medical Center — Elk Grove Village, Illinois, United States
• AMITA Health — Hinsdale, Illinois, United States
• Saint Luke's Mid America Heart — Kansas City, Kansas, United States
• University of Louisville — Louisville, Kentucky, United States
• Tulane University School of Medicine — New Orleans, Louisiana, United States
• Massachusetts General Hospital — Boston, Massachusetts, United States
• Boston Medical Center — Boston, Massachusetts, United States
• Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States
• Lahey Hospital — Burlington, Massachusetts, United States
• University of Michigan — Ann Arbor, Michigan, United States
• St. Joseph Mercy Health System — Ypsilanti, Michigan, United States
• Essentia Health — Duluth, Minnesota, United States
• University of Minnesota Medical Center Fairview — Minneapolis, Minnesota, United States
• Minneapolis Heart Institute (Foundation) — Minneapolis, Minnesota, United States
• Mayo Clinic — Rochester, Minnesota, United States
• Memorial Hospital at Gulfport — Gulfport, Mississippi, United States
• Washington University — St Louis, Missouri, United States
• Copper University Hospital — Camden, New Jersey, United States
• Hackensacjk University Medical Center — Hackensack, New Jersey, United States
• Central Arkansas Veterans Healthcare System — Little Rock, Arkansas, United States

Full record on ClinicalTrials.gov

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