Study to Evaluate Efficacy and Safety of Switching From TDF to TAF in Adults With Chronic Hepatitis B Who Are Virologically Suppressed

Completed · Phase 3 · Has a placebo group

Conditions studied: Chronic Hepatitis B

In brief

The primary objectives of this study are to evaluate the efficacy, safety, and tolerability of switching to tenofovir alafenamide (TAF) versus continuing tenofovir disoproxil fumarate (TDF) in virologically suppressed adults with chronic hepatitis B virus (HBV) infection.

Key facts

Study ID

NCT02979613

Run by

Gilead Sciences

People needed

490

Starts

2016-12-29

Expected to finish

2020-01-30

Last updated by the study team

2020-09-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Study site — Los Angeles, California, United States
• Study site — Palo Alto, California, United States
• Study site — Pasadena, California, United States
• Study site — San Diego, California, United States
• Study site — San Francisco, California, United States
• Study site — San Jose, California, United States
• Study site — Baltimore, Maryland, United States
• Study site — Boston, Massachusetts, United States
• Study site — Novi, Michigan, United States
• Study site — Flushing, New York, United States
• Study site — Flushing, New York, United States
• Study site — New York, New York, United States
• Study site — New York, New York, United States
• Study site — Philadelphia, Pennsylvania, United States
• Study site — Philadelphia, Pennsylvania, United States
• Study site — Nashville, Tennessee, United States
• Study site — Sugar Land, Texas, United States
• Study site — Edmonton, Canada
• Study site — Toronto, Canada
• Study site — Vancouver, Canada
• Study site — Hong Kong, Hong Kong
• Study site — Kowloon, Hong Kong
• Study site — Milan, Italy
• Study site — Goyang, Gyeonggi-d, South Korea
• Study site — Daegu, South Korea

Full record on ClinicalTrials.gov

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