Renal Uptake of Fatty Acids (FFA) in Patients With Idiopathic Uric Acid Nephrolithiasis (IUAN)
Withdrawn before enrolling · Not applicable
Conditions studied: Uric Acid Nephrolithiasis
In brief
The investigators will test the hypothesis that renal uptake of free (i.e. non-esterified) fatty acids (FFa) is increased in iuan. To accomplish this goal the investigators will measure renal FFa uptake FFa uptake in vivo in patients with iuan and matched non-stone forming subjects via single-photon emission computed tomography (SPeCT)/CT imaging. The definitive proof of the hypothesis rests on whether increased renal FFa uptake is demonstrable in humans with iuan.
Key facts
- Study ID
- NCT02975986
- Run by
- University of Texas Southwestern Medical Center
- People needed
- 0
- Starts
- 2017-01-01
- Expected to finish
- 2021-12-01
- Last updated by the study team
- 2020-10-05
Who can join
Age: 21 and older, up to 99. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- In the IUAN group (N=10), we will include adult subjects with documented IUAN, age > 21 years, either sex, any ethnicity
- In the Control group (N=10), we will include volunteers with no history of stone disease matched for age (within 5 years), gender, ethnicity, BMI (within 10%) and diabetes status
You may not qualify if…
- Contraindications to SPECT/CT, pregnancy, breastfeeding, chronic renal disease (eGFR < 60 ml/min/1.73m2), proteinuria, genetic diseases of the kidney, inborn defects of lipid metabolism, alcohol abuse, liver disease (patients with highly elevated total bilirubin, elevated liver enzymes AST, ALT and alkaline phosphatase and those with an established liver disease), anemia, and pharmacological treatment with insulin or insulin-sensitizing drugs such as thiazolidinediones (TZD).
- Patients on antidyslipidemic drugs, alkali therapy or allopurinol will be instructed to discontinue these drugs 2 weeks prior to the study.
Where it is running
- UT Southwestern Medical Center - Center for Mineral Metabolism — Dallas, Texas, United States
- UT Southwestern Medical Center — Dallas, Texas, United States
Full record on ClinicalTrials.gov
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