Prefrontal Cortical Engagement Through Non-Invasive Brain Stimulation in Schizophrenia
Completed · Not applicable
Conditions studied: Schizophrenia, Psychosis
In brief
Cognitive impairments in schizophrenia are the most debilitating aspect of the illness and poorly treated by current medications. This study investigates transcranial direct current stimulation (tDCS) - a safe, noninvasive weak electrical current delivery to stimulate brain function - as a novel therapeutic for cognition in schizophrenia. Integrating neurostimulation, electrophysiology and neuroimaging, this project aims to study tDCS effects on cognition by verifying therapeutic target engagement, evaluating the tolerability of tDCS sessions, and optimizing treatment parameters.
Key facts
- Study ID
- NCT02975973
- Run by
- Baylor College of Medicine
- People needed
- 15
- Starts
- 2016-11-01
- Expected to finish
- 2019-06-01
- Last updated by the study team
- 2020-11-25
Who can join
Age: 18 and older, up to 35. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- ages 18-35 years;
- within first five years of antipsychotic treatment;
- on stable doses of antipsychotic medication for at least one month;
- Clinically stable as defined by Clinical Global Impression-Severity scale (CGI-S) less than or equal to 4 (moderately ill);
- Mild to severe cognitive impairment in MATRICS Consensus Cognitive Battery (composite scores <40);
- DSM-5 MINI 7.0.2 criteria for schizophrenia or schizoaffective by patient SCID
You may not qualify if…
- Mental retardation as defined by pre-morbid IQ by Wechsler Test of Adult Reading at screening <70 or Spanish Word Accentuation Test;
- significant head injury;
- History of severe medical or neurological illnesses
- pregnancy or postpartum (<6 weeks after delivery or miscarriage);
- inability to provide informed consent;
- significant color blindness that affects task performance;
- Positive urine drug screen (exception for marijuana) or presence of substance use disorder within 1 month;
- Currently on benzodiazepines or mood stabilizers affecting GABA
Where it is running
- Baylor College of Medicine — Houston, Texas, United States
Full record on ClinicalTrials.gov
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