Adiposity and Airway Inflammation in HIV-Associated Airway Disease

Completed

Conditions studied: Asthma, HIV, Adiposity

In brief

The goals of this study are to 1) examine the relationships among inflammation, obesity, and asthma in people with HIV and 2) to test if special subtypes of cells or markers are present in the blood and lungs of people with HIV with asthma compared to those without asthma.

Key facts

Study ID

NCT02975258

Run by

University of Pittsburgh

People needed

102

Starts

2015-09-01

Expected to finish

2017-09-01

Last updated by the study team

2017-10-13

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18 years of age or older
• Subject who have been previously determined to be HIV positive through testing

You may not qualify if…

• Pregnancy or breast-feeding
• Contraindication to pulmonary function testing (i.e. abdominal or cataract surgery within 3 months, recent myocardial infarction, etc.)
• Heart condition such as tachycardia, angina or arrhythmias
• Acute respiratory infection: increasing respiratory symptoms or fever (temperature >100.4°F [38°C]) within 4 weeks of study entry
• Hospitalization within 4 weeks of study entry
• Uncontrolled hypertension at screening visit (systolic > 160 mm Hg or diastolic > 100 mm Hg) from an average of two or more readings (participant may return for screening after blood pressure is controlled)
• Active cancer requiring systemic chemotherapy or radiation
• Active infection of lungs, brain, or abdomen; or intravenous drug use or alcohol use that will impair ability to complete study investigations in the opinion of the investigator
• History of prior lung resection

Where it is running

• University of Pittsburgh — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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