Short Term Genetic Effects of Chemotherapy on Male Germ Cells

Completed

Conditions studied: Cancer

In brief

This study will determine the short-term effects of chemotherapy on sperm DNA.The study involves the collection of semen sample through ejaculation prior to initiation of chemotherapy and up to three time points after initiation of chemotherapy.

Key facts

Study ID

NCT02975245

Run by

University of Pittsburgh

People needed

200

Starts

2013-02-01

Expected to finish

2025-04-01

Last updated by the study team

2025-09-19

Who can join

Age: 18 and older, up to 50. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Be scheduled to undergo treatment with chemotherapeutic agents for a medical indication
• Be able to produce semen samples prior to chemotherapy and one week after first round of chemotherapy

You may not qualify if…

• Men who have previously been treated with chemotherapeutic agents.
• Men with significant oligospermia or azospermia.

Where it is running

• Magee-Womens Hospital — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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