Effects of Intermittent Hypoxia (IH) on Metabolism and Dysglycemia, in Overweight/Obese Persons SCI

Completed · Not applicable · Has a placebo group

Conditions studied: Spinal Cord Injuries, Obesity, Insulin Resistance

In brief

The purpose of this research is to examine changes in blood glucose control and metabolism in individuals with SCI and non injured controls at rest and during exercise after five days of exposure to IH. This response will be compared with breathing normal room air (a SHAM control).

Key facts

Study ID

NCT02973438

Run by

University of Miami

People needed

6

Starts

2016-12-01

Expected to finish

2018-12-01

Last updated by the study team

2020-12-17

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• SCI only:
• Lower extremity weakness or paralysis at C5 or below resulting from spinal cord injury for at least one year.
• ASIA Classification A-D Overweight or obese as classified by a Body Mass Index (BMI) (kg/m2) of ≥ 25.0 (CON) and ≥ 22.0 (SCI).
• SCI and non injured control:
• Resting SaO2 ≥ 95%
• Exclusion Criteria (SCI and non injured control):
• Currently hospitalized
• Resting heart rate ≥120 BPM
• Resting systolic blood pressure >180 mm Hg
• Resting diastolic Blood Pressure >100 mmHg
• Self-reported history of unstable angina or myocardial infarction within the previous month
• Previous cardiac surgery or condition that evidences ischemic heart disease
• Cardiopulmonary complication such as COPD
• Pregnancy determined by urine testing in sexually active females.

Where it is running

• The Miami Project to Cure Paralysis — Miami, Florida, United States

Full record on ClinicalTrials.gov

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