Fibrinolysis Compared to Thoracoscopy for Pleural Infection

Completed · Not applicable

Conditions studied: Pleural Infection, Pleural Diseases

In brief

The purpose of this prospective randomized clinical trial is to compare two currently accepted standard-of-care treatment strategies: Medical thoracoscopy as compared to instillation of intrapleural tissue Plasminogen Activator (TPA) and human recombinant Deoxyribonuclease (DNase) for the management of empyema or complex parapneumonic effusion (CPPE) in adults.

Key facts

Study ID

NCT02973139

Run by

Beth Israel Deaconess Medical Center

People needed

32

Starts

2017-07-14

Expected to finish

2019-11-01

Last updated by the study team

2019-12-26

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects >18 years old with:
• Evidence of empyema or complex parapneumonic effusion

You may not qualify if…

• Age <18 years
• Pregnancy
• Inability to give informed written consent
• Previous thoracic surgery or thrombolytic therapy for pleural infection
• Medical thoracoscopy cannot be performed within 48 hours
• Hemodynamic instability or severe hypoxemia
• Non corrected coagulopathy
• Homogeneously echogenic effusion on pleural ultrasonography

Where it is running

• Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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