A Study of Lanabecestat (LY3314814) in Early Alzheimer's Disease Dementia

Stopped early · Phase 3 · Has a placebo group

Conditions studied: Alzheimer's Disease

In brief

This study is an extension of study I8D-MC-AZES (NCT02245737), the AMARANTH study. The purpose of this study is to evaluate the effectiveness of the study drug lanabecestat in participants with early Alzheimer's disease dementia at the time of entry into study I8D-MC-AZES.

Key facts

Study ID

NCT02972658

Run by

AstraZeneca

People needed

421

Starts

2017-03-15

Expected to finish

2018-10-02

Last updated by the study team

2019-12-03

Who can join

Age: 55 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participants previously enrolled in AMARANTH (NCT02245737) who meet eligibility criteria for delayed-start I8D-MC-AZFD.

You may not qualify if…

• Participants who participate in AMARANTH (NCT02245737) who develop new conditions precluding them from enrolling into I8D-MC-AZFD.

Where it is running

• Territory Neurology & Research Institute — Tucson, Arizona, United States
• Pacific Research Network Inc — San Diego, California, United States
• Mile High Research Center — Denver, Colorado, United States
• Institute for Neurodegenerative Disorders — New Haven, Connecticut, United States
• Georgetown University Medical Center — Washington D.C., District of Columbia, United States
• Brain Matters Research — Delray Beach, Florida, United States
• Compass Research — Orlando, Florida, United States
• IMIC, Inc. — Palmetto Bay, Florida, United States
• Roskamp Institute — Sarasota, Florida, United States
• Suncoast Neuroscience Associates — St. Petersburg, Florida, United States
• Premiere Research Institute at Palm Beach Neurology — West Palm Beach, Florida, United States
• The Multiple Sclerosis Center of Atlanta — Atlanta, Georgia, United States
• University of Chicago Medical Center — Chicago, Illinois, United States
• Community Clinical Research Center — Anderson, Indiana, United States
• Boston Center for Memory — Newton, Massachusetts, United States
• Hattiesburg Clinic — Hattiesburg, Mississippi, United States
• Memory Enhancement Center of America, Inc. — Eatontown, New Jersey, United States
• The Cognitive and Research Center of NJ — Springfield, New Jersey, United States
• Advanced Memory Research Institute of New Jersey — Toms River, New Jersey, United States
• Integrative Clinical Trials, LLC — Brooklyn, New York, United States
• Columbia University Medical Center — New York, New York, United States
• University of Rochester School of Medicine — Rochester, New York, United States
• Valley Medical Primary Care — Centerville, Ohio, United States
• Lindner Research Center — Cincinnati, Ohio, United States
• Banner Alzheimer's Institute — Phoenix, Arizona, United States

Full record on ClinicalTrials.gov

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