Does Propranolol Attenuate Inflammatory Responses to a Psychological Stressor?

Completed · Phase 4 · Has a placebo group

Conditions studied: Stress, Psychological, Inflammation, Cortisol, Sympathetic Nervous System

In brief

This randomized, double-blind, placebo-controlled study of propranolol will shed important light on how sympathetic nervous system (SNS) activation influences psychological and inflammatory responses to acute stress. Results from this study will inform both the basic science literature that is attempting to map the physiological mechanisms by which psychological stress may lead to poor mental and physical health, and may also ultimately have therapeutic relevance for individuals who are experiencing high levels of stress that is putting their health at risk. Utilizing a psychopharmacological approach allows for the circumvention of many of the challenges of conducting this research in human populations, and will allow for conclusions regarding causality, given that SNS activation will be experimentally manipulated, rather than relying on correlational measures of SNS activity that are difficult to assess and are not appropriate for asking if SNS activity causes changes in psychology and biology.

Key facts

Study ID
NCT02972554
Run by
University of North Carolina, Chapel Hill
People needed
92
Starts
2016-01-26
Expected to finish
2017-10-10
Last updated by the study team
2018-12-19

Who can join

Age: 18 and older, up to 25. Sex: any. Healthy volunteers: accepted.

Where it is running

Full record on ClinicalTrials.gov

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