Efficacy of Haloperidol vs. Metoclopramide for Treatment of Acute Headaches and Migraines in the Emergency Department
Stopped early · Phase 4
Conditions studied: Headache, Migraine
In brief
Metoclopramide (Reglan) is a common agent used for relief of headaches in the emergency department (ED).In this study the investigators seek to explore another option for treatment of headaches in the ED, one that may be more efficacious and efficient. Haloperidol (Haldol), a butyrophenone class of medication, is thought to act by affecting the dopamine 2 receptor in the brain. By exploring haloperidol as an option for treatment, the investigators hope to discover a more efficient and effective medication for the treatment of non-traumatic headaches, thereby decreasing a patient's length of stay in the department and decreasing the rate of return visits for continued discomfort from the same headache. This study could lead to the increased usage of haloperidol as a first line agent in the treatment of prolonged headaches presenting to the ED.
Key facts
- Study ID
- NCT02972502
- Run by
- OhioHealth
- People needed
- 66
- Starts
- 2014-02-01
- Expected to finish
- 2017-04-24
- Last updated by the study team
- 2018-10-23
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients who present with a headache or migraine with onset less than or equal to 72 hours
You may not qualify if…
- Known pregnancy
- Breast-feeding women
- Known history of arrhythmias or QT prolongation (450 ms)
- Known adverse effects to haloperidol, diphenhydramine (Benadryl) or metoclopramide
- Subarachnoid hemorrhage
- Headaches caused by trauma, meningitis
- Congestive heart failure
- Parkinson's Disease
- Dementia
- Pheochromocytoma
- History of glaucoma
- History of seizures
- Non-English speaking patients
Where it is running
- OhioHealth Doctors Hospital — Columbus, Ohio, United States
Full record on ClinicalTrials.gov
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