Pharmacogenomics of Warfarin in Hispanics and Latinos
Recruiting now
Conditions studied: Thrombosis, Hemorrhage
In brief
Warfarin is a commonly used blood thinner to treat and prevent blood clots. It is important to take the right dose of warfarin because too much can increase the risk of bleeding and too little can increase the risk of blood clots. This is why patients are closely monitored especially when they begin warfarin therapy. When clinicians prescribe warfarin, they have to consider different factors such as patient's age, body size, diet, and other medications that can interact with warfarin. Certain genes have also been found to affect warfarin dose. Individuals have variations in these genes, which can help explain why some patients need higher dose and others require less. These factors have been used to better predict a patient's warfarin dose requirement. However, these predictions were created based on Caucasian populations and they may not be accurate in predicting a safe warfarin dose if a patient is not Caucasian. This study aims to identify new genetic variation that affects warfarin dosing in Hispanic and Latino populations and try to better predict a Hispanic or Latino patient's warfarin dose requirement.
Key facts
- Study ID
- NCT02972385
- Run by
- University of Arizona
- People needed
- 400
- Starts
- 2016-09-01
- Expected to finish
- 2026-09-01
- Last updated by the study team
- 2024-06-27
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- At least 18 years of age
- Ability to give informed consent
- Therapeutic INR for at least 2 consecutive clinic visits
- Self-identifies as Hispanic or Latino
You may not qualify if…
- Less than 18 years old
- Unable to give informed consent
- Severe hepatic impairment
Where it is running
- Banner University Medical Center - Tucson — Tucson, Arizona, United States (enrolling)
Full record on ClinicalTrials.gov
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