The Effect of Isotretinoin on the Etonogestrel Contraceptive Implant

Completed

Conditions studied: Contraception

In brief

This exploratory study will fill a knowledge gap regarding the pharmacokinetic effects of isotretinoin on the etonogestrel (ENG) contraceptive implant.

Key facts

Study ID

NCT02967055

Run by

University of Colorado, Denver

People needed

9

Starts

2017-02-15

Expected to finish

2019-06-30

Last updated by the study team

2020-08-11

Who can join

Age: 18 and older, up to 45. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Have a secondary form of non-hormonal contraception or abstain during isotretinoin therapy and four weeks afterwards
• Have at least two negative pregnancy tests at least 19 days apart prior to initiating isotretinoin therapy
• Have normal baseline laboratory evaluation including liver function tests, basic metabolic panel, and complete blood count
• Willing to abstain from taking any Vitamin A supplement during the study period
• Have a Body Mass Index (BMI) >= 18.5

You may not qualify if…

• Currently breastfeeding
• Known contraindications to isotretinoin
• Currently taking any known cytochrome P-450 3A4 enzyme inducers or inhibitors

Where it is running

• University of Colorado Denver — Aurora, Colorado, United States

Full record on ClinicalTrials.gov

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