4-Repeat Tauopathy Neuroimaging Initiative - Cycle 2

Completed

Conditions studied: Corticobasal Degeneration (CBD), Corticobasal Syndrome (CBS), Cortical-basal Ganglionic Degeneration (CBGD), Progressive Supranuclear Palsy (PSP), Nonfluent Variant Primary Progressive Aphasia (nfvPPA), Oligosymptomatic/Variant Progressive Supranuclear Palsy (o/vPSP)

In brief

The goal of this study is to identify the most reliable methods of analysis for tracking CBD, PSP, and o/vPSP over time. The results from this study may be used in the future to calculate statistical power for clinical drug trials. The study will also provide information about the relative value of novel imaging techniques for diagnosis, as well as the value of imaging techniques versus testing of blood, urine, and cerebrospinal fluid (CSF) 'biomarkers'.

Key facts

Study ID

NCT02966145

Run by

University of California, San Francisco

People needed

293

Starts

2016-01-01

Expected to finish

2024-02-28

Last updated by the study team

2025-04-13

Who can join

Age: 40 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• No known history of neurological disease, or meet criteria for one of the following: Corticobasal Syndrome or Degeneration (CBS or CBD); Progressive Supranuclear Palsy (PSP); or Oligo- or Variant- Progressive Supranuclear Palsy (o/vPSP)
• Needs a reliable study partner who has frequent contact with the participant, who is available to provide information about the participant, and who can accompany the participant to research visits as needed
• Must be willing and able to undergo testing procedures, which include longitudinal follow-up visits
• Must be able to walk five steps with minimal assistance

You may not qualify if…

• Significant neurological disease other than CBD, PSP, or a variant PSP syndrome.
• Presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, or metal fragments or metal objects in the eyes, skin, or body
• In the site investigator's opinion, inability to complete sufficient key study procedures, or some other equivalent assessment of impairment

Where it is running

• University of California, San Diego (UCSD) — San Diego, California, United States
• University of California, San Francisco (UCSF) — San Francisco, California, United States
• Johns Hopkins University — Baltimore, Maryland, United States
• Harvard University - Massachusetts General Hospital — Charlestown, Massachusetts, United States
• Mayo Clinic - Rochester — Rochester, Minnesota, United States
• Columbia University — New York, New York, United States
• University of Pennsylvania — Philadelphia, Pennsylvania, United States
• University of Toronto — Toronto, Ontario, Canada

Full record on ClinicalTrials.gov

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