Fixed Low-dose Heparin Versus Standard Adjusted-dose Heparin Infusion in Adults Receiving Venovenous ECMO With a Heparin Bonded Circuit.

Withdrawn before enrolling · Not applicable

Conditions studied: Acute Respiratory Failure, Extracorporeal Membrane Oxygenation Complication, Bleeding

In brief

Heparin is a blood thinner used to prevent blood clots in patients on a form of life-support called ECMO. Heparin can cause bleeding - the most common complication of ECMO. New materials used in ECMO machines may help prevent clots - this could allow the use of lower doses of heparin which might reduce the risk of bleeding. Our study will compare low dose to high dose heparin in patients on ECMO. We think low dose heparin may be adequate to prevent clotting, but may cause less bleeding and be safer for patients.

Key facts

Study ID

NCT02966080

Run by

University of Arizona

People needed

0

Starts

2016-12-01

Expected to finish

2021-02-01

Last updated by the study team

2017-08-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• on ECMO for acute respiratory failure, achieving ECMO blood flow rate >3L/min,
• patient or surrogate able to speak/understand English or Spanish

You may not qualify if…

• History of heparin-induced thrombocytopenia, decision by clinicians to run ECMO off heparin due to high bleeding risk,
• pregnancy

Where it is running

• Banner - University Medical Center Phoenix — Phoenix, Arizona, United States

Full record on ClinicalTrials.gov

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