Investigation and Modulation of the Mu-Opioid Mechanisms in Migraine (in Vivo)

Stopped early · Not applicable · Has a placebo group

Conditions studied: Migraine

In brief

This study investigates whether non-invasive brain stimulation, given for 20 minutes/once per day for ten days (M-F) can reduce migraine pain. Thirty patients will receive this treatment, while thirty will receive a "sham" procedure. Up to thirty healthy volunteers will be asked to undergo baseline assessments only (imaging, but no brain stimulation). Healthy volunteer data may be used from a prior study (NINDS-K23062946 project \[IRBMED #HUM00027383; Dr. Alexandre DaSilva, Principal Investigator\]).

Key facts

Study ID

NCT02964741

Run by

University of Michigan

People needed

44

Starts

2017-02-22

Expected to finish

2021-08-01

Last updated by the study team

2022-08-26

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Episodic migraine (ICHD-3-beta) for at least 6 months, with at least one attack per month and less than 15 attacks per month
• No intake of opiate medication for the past six months
• No overuse of analgesic medication, defined as regular intake on ≥15 days per month for more than 3 months
• Willing to limit the introduction of new treatments for headache management

You may not qualify if…

• Presence of any other systemic or chronic pain disorder
• History or current evidence of a psychotic disorder (e.g. schizophrenia) or substance abuse; bipolar or severe major depression, as evidenced by Beck Depression score of ≥ 30
• History of neurological disorder (e.g. epilepsy, stroke, neuropathy, neuropathic pain)
• Prior use of tDCS
• Current use of opioid pain medications

Where it is running

• University of Michigan School of Dentistry — Ann Arbor, Michigan, United States

Full record on ClinicalTrials.gov

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