On-Demand Oxygen Delivery System Study
Running, not enrolling · Not applicable
Conditions studied: Oxygen Delivery, Patient Monitoring
In brief
The main goal of this study is to determine if supplemental oxygen given only when the patient is inspiring (demand delivery) is more effective than constant-flow oxygen given during all phases of the breath regardless if the patient is breathing it in. A previous study in volunteers (NCT02886312) showed that the oxygen saturation in the blood and the concentration of oxygen breathed out from the lungs (end-tidal oxygen) was higher when given in demand (inhalation only) mode. A secondary goal is to determine in patients, whether turning oxygen delivery off during expiration improves the accuracy of end-tidal CO2 (Carbon Dioxide) monitoring. This was found to be the case in the previous volunteer study. The investigators want to determine if these improvements are also observable in relatively healthy patients undergoing procedural sedation and analgesia. The efficacy of the demand mode will be determined by measuring the resulting difference in oxygen saturation and end-tidal oxygen levels. The investigators will alternate between traditional oxygen delivery (continuous flow) and demand delivery (flow only during inhalation) for two minutes in each mode after which oxygen saturation and end-tidal oxygen will be measured. End-tidal CO2 measurement will be compared with those during the brief time when O2 flow is stopped.
Key facts
- Study ID
- NCT02962570
- Run by
- University of Utah
- People needed
- 100
- Starts
- 2016-11-01
- Expected to finish
- 2026-11-01
- Last updated by the study team
- 2026-04-30
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- ASA class I-III
You may not qualify if…
- Procedures scheduled for a lime less than 20 minutes
- Age < 18 years
- Baseline SpO2 (arterial oxygen saturation as measured by pulse oximetry) < 93% on room air
- ARDS (Acute respiratory distress syndrome), lung disease, cardiovascular disease
- ASA class IV or above
- Pregnant women.
Where it is running
- University of Utah — Salt Lake City, Utah, United States
Full record on ClinicalTrials.gov
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