Effects of Sublingual and Transdermal Administration of Nitroglycerin for Coronary CT Angiography on Image Quality

Completed · Phase 4

Conditions studied: Coronary Artery Disease

In brief

To evaluate image quality of coronary CT angiography (cCTA) after sublingual and transdermal administration of Nitroglycerin. Aim of this prospective research study is to investigate equivalence on image quality after sublingual or transdermal Nitroglycerin administration (H0). Furthermore, the feasibility of transdermal Nitroglycerin administration will be evaluated.

Key facts

Study ID

NCT02961946

Run by

Massachusetts General Hospital

People needed

198

Starts

2017-03-15

Expected to finish

2018-08-02

Last updated by the study team

2019-09-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Scheduled cCTA with contrast.
• Able to comprehend and sign the consent form.

You may not qualify if…

• Known hypersensitivity to glyceryl trinitrate, and related organic nitrates.
• Acute circulatory failure associated with marked hypotension (shock).
• Conditions associated with elevated intracranial pressure, cerebral haemorrhage and head trauma.
• Closed-angle glaucoma.
• Phosphodiesterase type 5 (PDE5) inhibitors such as sildenafil (Viagra®), tadalafil (Cialis), or vardenafil (Levitra) within the last 24 hours
• Unstable clinical conditions (i.e. hemodynamic instability, arrhythmias)
• Critical aortic stenosis
• Systolic blood pressure < 90 mmHg
• Pregnant or lactating female; premenopausal women with a positive urine pregnancy test.
• Age under 18
• Unwilling or unable to inform consent.

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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