A Laboratory Model of Increasing Delta-9-tetrahydrocannabinol (THC) Potency on Cigarette Smoking

Completed · Phase 1 · Has a placebo group

Conditions studied: Tobacco Use

In brief

The objective of the proposed research is to investigate how smoking increasing potency of THC (i.e., the psychoactive ingredient in marijuana) changes tobacco cigarette smoking behavior, urges, subjective effects, and abuse liability. This study will be a within-subjects, placebo-controlled study in our clinical laboratory of the effect of active vs. placebo marijuana on cigarette puff topography, exhaled carbon monoxide, urge, subjective effects, and abuse liability among 7 adults who smoke both marijuana and tobacco cigarettes.

Key facts

Study ID

NCT02961309

Run by

Battelle Memorial Institute

People needed

9

Starts

2018-05-07

Expected to finish

2019-09-30

Last updated by the study team

2019-10-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Current US resident;
• Age ≥ 18 years;
• Self-reported smoking of marijuana no more than three days per week within the past year;
• Self-report past-month smoking of marijuana;
• Self-report daily smoking of at least five cigarettes per day within the past year;
• Cotinine ≥ 100 ng/mL at the in-person screening visit; and
• Able to read, understand, and sign informed consent.

You may not qualify if…

• Meets Diagnostic and Statistical Manual-5 (DSM-5) criteria for current (i.e., past year) or past (i.e., lifetime) cannabis use disorder;
• Meets DSM-5 criteria for any current Axis I disorder, other than tobacco use disorder;
• Self-reported current desire to stop marijuana or tobacco use, defined as 7 or greater on an 11-rung (scaled of 1-10) Contemplation Ladder for each;
• Self-reported asthma or chronic obstructive pulmonary disease; and
• Among females, current pregnancy or lactation.

Where it is running

• Battelle Memorial Institute — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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