Optimizing Outcomes of Treatment-Resistant Depression in Older Adults

Completed · Phase 4

Conditions studied: Treatment Resistant Depression, Major Depressive Disorder, Treatment-Refractory Depression, Late Life Depression, Geriatric Depression

In brief

The purpose of this research study is to assess which antidepressants work the best in older adults who have treatment-resistant depression (TRD).

Key facts

Study ID

NCT02960763

Run by

Washington University School of Medicine

People needed

742

Starts

2017-02-24

Expected to finish

2021-09-01

Last updated by the study team

2024-10-03

Who can join

Age: 60 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Men and women aged 60 and older
• Current Major Depressive Disorder (MDD)
• Failure to respond adequately to two or more antidepressant treatment trials of recommended dose and length
• Patient Health Questionnaire-9 (PHQ-9) score of 10 or higher

You may not qualify if…

• Inability to provide informed consent
• Dementia
• Lifetime diagnosis of bipolar I or II disorder, schizophrenia, schizoaffective disorder, schizophreniform disorder, delusional disorder, or current psychotic symptoms
• High risk for suicide and unable to be managed safely in the clinical trial
• Contraindication to proposed study medications, as determined by study physician including history of intolerance or non-response to proposed medications.
• Non-correctable, clinically significant sensory impairment interfering with participation
• Unstable medical illness, including delirium, uncontrolled diabetes mellitus, hypertension, hyperlipidemia, or cerebrovascular or cardiovascular risk factors that are not under medical management.
• Moderate to severe substance or alcohol use disorder

Where it is running

• UCLA Late-Life Mood, Stress, and Wellness Research Program — Los Angeles, California, United States
• Washington University School of Medicine Healthy Mind Lab — St Louis, Missouri, United States
• Columbia University Adult and Late Life Depression Clinic — New York, New York, United States
• UPMC Late-Life Depression, Evaluation, Prevention, and Treatment Program — Pittsburgh, Pennsylvania, United States
• Centre for Addiction and Mental Health — Toronto, Ontario, Canada

Full record on ClinicalTrials.gov

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