Incident COronary EveNts Identified by Computed Tomography
Completed
Conditions studied: Atherosclerosis
In brief
The Incident COronary EveNts Identified by Coronary Tomography (ICONIC) trial is a nested, case-control study derived from the dynamic CONFIRM registry, and is based on propensity scoring methods to match subjects with (cases) or without (controls) acute coronary syndrome (ACS). Our primary objective is to determine CCTA-based atherosclerotic plaque characteristics that would help elucidate precursors of incident ACS, with the secondary objective being an analysis of gender-specific disparities.
Key facts
- Study ID
- NCT02959099
- Run by
- Weill Medical College of Cornell University
- People needed
- 476
- Starts
- 2012-07-20
- Expected to finish
- 2017-04-30
- Last updated by the study team
- 2019-11-19
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥18 years.
- Adjudicated STEMI / NSTEMI / UA / Unclassified MI (except for type 4a, 4b, or 5 MI)
- Baseline CCTA.
You may not qualify if…
- Myocardial infarction not meeting the definition of ACS with missing cardiac biomarkers.
- Prior history of CAD (revascularization or MI).
- Prior revascularization (PCI or CABG).
- ACS in a previously revascularized segment.
- Type 4a, 4b, or 5 MI.
- Controls
- Inclusion criteria:
- Age ≥18 years.
- Propensity score matched.
- Exclusion criteria:
- Prior history of CAD (revascularization or MI).
- Death as an outcome.
Where it is running
- Baptist Hospital of Miami — Miami, Florida, United States
- Walter Reed Army Medical Center — Bethesda, Maryland, United States
- William Beaumont Hospital — Royal Oak, Michigan, United States
- Innsbruck Medical University — Innsbruck, Austria
- University of Ottawa Heart Institute — Ottawa, Ontario, Canada
- Providence Health Care St. Paul's Hospital — Vancouver, Canada
- University of Munich — Munich, Germany
- Department of Clinical Sciences and Community Health, University of Milan & Centro Cardiologico Monzino, IRCCS — Milan, Italy
- University Hospital of Parma — Parma, Italy
- Leiden University Medical Center — Leiden, Netherlands
- Hospital da Luz — Lisbon, Portugal
- Seoul National University Hospital — Seoul, South Korea
- Severance Cardiovascular Hospital — Seoul, South Korea
Full record on ClinicalTrials.gov
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