Multicenter Cohort Study on Osteoporosis

Recruiting now

Conditions studied: Osteoporosis

In brief

This is a multicenter cohort study on osteoporosis in nine cities of China which locate in the east, south, north, west, middle of China. At least 3000 middle-aged and elderly permanent residents (women aged from 45 to 79, and men aged from 50 to 79) in every city will be enrolled. Residents with severe mental diseases, physical diseases or acute infectious diseases who could not cooperate with the survey as well as lactating or pregnant women were excluded. All the enrolled residents who signed informed consent will finish questionnaire including demographic characteristics, history of smoking, alcohol drinking, falls and fracture, family genetic history, chronic diseases and medicine,diary and physical practice，stool and urine status. Osteoporosis risk, health status, constitution of traditional Chinese medicine (TCM),symptoms of kidney yang deficiency in TCM，living environment,sweating status will be evaluated. Fasting blood glucose test and other blood tests for liver and kidney function,bone metabolism，vitamins，vitamin D metabolism and transportation as well as calcium and phosphate metabolism, will be performed. Bone mineral density and physical examinations (height, weight, waist circumference, hip circumference,grip,sit-to-stand test, tongue coating and pulse) will also be performed at enrollment and every two years after enrollment. DNA of blood cells will be preserved for specific study such as SNP analyses.Tongue coating and feces will be preserved for microflora analyses.

Key facts

Study ID

NCT02958020

Run by

Shanghai University of Traditional Chinese Medicine

People needed

50000

Starts

2016-11-01

Expected to finish

2028-10-01

Last updated by the study team

2021-09-23

Who can join

Age: 45 and older, up to 79. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• permanent residents
• women aged from 45 to 79, and men aged from 50 to 79

You may not qualify if…

• severe mental diseases, physical diseases or acute infectious diseases who could not cooperate with the survey.
• lactating or pregnant women.

Where it is running

• Longhua Hospital, Shanghai University of TCM — Shanghai, China (enrolling)
• First People's Hospital of Nankang District, Ganzhou City — Ganzhou, Jiangxi, China (enrolling)
• Shandong Provincial Hospital of Traditional Chinese Medicine — Jinan, Shandong, China (enrolling)
• Shenzhen Pingle Orthopedic Hospital — Shenzhen, Guangdong, China (enrolling)
• Dongzhimen Hospital, Beijing — Beijing, China (enrolling)
• Wangjing Hospital, China Academy of Chinese Medical Sciences — Beijing, China (enrolling)
• Affiliated Hospital of Changchun University of Traditional Chinese Medicine — Changchun, China (enrolling)
• Guangdong Provincial Hospital of Traditional Chinese Medicine — Guangzhou, China (enrolling)
• Guangzhou Kingmed Diagnostics Co., Ltd. — Guangzhou, China (enrolling)
• The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine — Guangzhou, China (enrolling)
• Gansu Provincial Hospital of Traditional Chinese Medicine — Lanzhou, China (enrolling)
• Yunnan Provincial Hospital of Traditional Chinese Medicine — Kunming, Yunnan, China

Full record on ClinicalTrials.gov

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