Beta Blockade in in Traumatic Brain Injury

Completed · Phase 4

Conditions studied: Brain Injuries, Traumatic

In brief

The purpose of this study is test the effect of beta-adrenergic blockade on mortality in patients with traumatic brain injury with the hypothesis being that the addition of beta blockade to the treatment regime of this patient population will lower mortality and supress the catecholamine surge that accompanies traumatic brain injury as compared to those who do not receive beta blockade. Half the patients will be randomized to receive propranolol and half will be randomized to receive no beta blocker.

Key facts

Study ID

NCT02957331

Run by

University of Tennessee

People needed

26

Starts

2016-01-01

Expected to finish

2018-05-01

Last updated by the study team

2020-06-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects ages 18 and older with isolated traumatic brain injury as defined by Glasgow Coma Scale score 12 or less with documented injury on head CT and limited injury to the rest of the body. (Abbreviated Injury Scale (AIS) must be < or = 3 from other body areas.)

You may not qualify if…

• Subjects <18 years of age, prisoners, those on beta-blockers as home medication, those who are pregnant, those with severe liver disease, those taking vasopressors, those with acute coronary syndrome, and those with severe injury to another body region (AIS >3).
• Subjects who cannot be enrolled within 48 hours of admission following acute resuscitation will not be enrolled into this study.

Where it is running

• Regional One Health — Memphis, Tennessee, United States

Full record on ClinicalTrials.gov

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