Phase 2 Study of Glesatinib, Sitravatinib or Mocetinostat in Combination With Nivolumab in Non-Small Cell Lung Cancer

Stopped early · Phase 2

Conditions studied: Carcinoma, Non-Small-Cell Lung

In brief

The study will evaluate the clinical activity of nivolumab in combination with 3 separate investigational agents, glesatinib, sitravatinib, or mocetinostat.

Key facts

Study ID

NCT02954991

Run by

Mirati Therapeutics Inc.

People needed

161

Starts

2016-11-07

Expected to finish

2021-11-04

Last updated by the study team

2024-04-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of non-small cell lung cancer.
• Prior treatment with a checkpoint inhibitor (as appropriate per cohort)
• Adequate bone marrow and organ function

You may not qualify if…

• Uncontrolled tumor in the brain
• Unacceptable toxicity with prior checkpoint inhibitor
• Impaired heart function

Where it is running

• Yuma Regional Medical Center — Yuma, Arizona, United States
• Beverly Hills Cancer Center — Beverly Hills, California, United States
• City of Hope National Medical Center — Duarte, California, United States
• University of California San Diego — La Jolla, California, United States
• University of California San Francisco Comprehensive Cancer Center — San Francisco, California, United States
• University of California Los Angeles - Torrance - Community Cancer Care — Santa Clarita, California, United States
• Rocky Mountain Cancer Centers - Denver - Midtown — Denver, Colorado, United States
• Baptist Health — Louisville, Kentucky, United States
• Henry Ford Hospital — Detroit, Michigan, United States
• Minnesota Oncology Hematology, P.A. — Minneapolis, Minnesota, United States
• University of Minnesota Masonic Cancer Center — Minneapolis, Minnesota, United States
• Saint Francis Cancer Treatment Center — Grand Island, Nebraska, United States
• Oncology Hematology Care-Blue Ash — Cincinnati, Ohio, United States
• University Hospitals Cleveland Medical Center — Cleveland, Ohio, United States
• Ohio State University Comprehensive Cancer Center — Columbus, Ohio, United States
• Hematology Oncology Associates - Barnett Office — Medford, Oregon, United States
• Northwest Cancer Specialists, P.C. — Tualatin, Oregon, United States
• Fox Chase Cancer Center — Philadelphia, Pennsylvania, United States
• Vanderbilt University — Nashville, Tennessee, United States
• Texas Oncology - South Austin — Austin, Texas, United States
• USOR - Texas Oncology - Denison Cancer Center — Denison, Texas, United States
• MD Anderson Cancer Center — Houston, Texas, United States
• Texas Oncology - Tyler — Tyler, Texas, United States
• Virginia Cancer Specialist — Fairfax, Virginia, United States
• University of Wisconsin — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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