Dietary Sources of Lysophospholipids

Stopped early

Conditions studied: Obesity, Cardiovascular Risk Factor, Hyperlipidemia

In brief

This study aims to test the hypothesis that dietary intake of phosphatidylcholine (PC) and lysophosphatidylcholine (LPC) acutely alters plasma lysophosphatidic acid (LPA) levels and autotaxin activity in normal weight and obese subjects.

Key facts

Study ID

NCT02952638

Run by

Susan Smyth

People needed

44

Starts

2015-07-14

Expected to finish

2015-12-01

Last updated by the study team

2021-07-21

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 18 to 60 years old
• Body Mass Index of 20 and above
• Must be able to consume a low fat meal, unlimited fruits and vegetables and not eating after midnight the night before the lipid tolerance test
• Report to the clinical research unit fasting (no food since the meal the night before)
• Able to consume a liquid meal consisting of a commercial nutritional product supplemented with fat
• Able to have an indwelling catheter placed on one arm and have hourly blood draws for 8 hours

You may not qualify if…

• Unstable medical condition (recent or unstable cardiovascular disease)
• Active cancer
• Renal insufficiency Glomerular Filtration Rate <30
• Use of steroids
• Chronic inflammatory conditions
• Use of anticoagulants, anti-inflammatory, or lipid-lowering medications
• Lipodystrophy
• GI conditions that result in lipid intolerance
• Pregnant women have a tendency to be anemic and therefore will be excluded.

Where it is running

• University of Kentucky Dept of Cardiology — Lexington, Kentucky, United States

Full record on ClinicalTrials.gov

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