Study of Iopofosine I-131 (CLR 131) in Select B-Cell Malignancies (CLOVER-1) With Expansion in Waldenstrom

Running, not enrolling · Phase 2

Conditions studied: Waldenstrom Macroglobulinemia, Multiple Myeloma, Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Lymphoplasmacytic Lymphoma, Marginal Zone Lymphoma, Mantle Cell Lymphoma, Diffuse Large B Cell Lymphoma, Central Nervous System Lymphoma

In brief

Part A of this study evaluates iopofosine I 131 (CLR 131) in patients with select B-cell malignancies (multiple myeloma( MM), indolent chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL), lymphoplasmacytic lymphoma (LPL)/Waldenstrom Macroglobulinemia (WM), marginal zone lymphoma (MZL), mantle cell lymphoma (MCL), diffuse large B-cell lymphoma (DLBCL), and central nervous system lymphoma (CNSL) who have been previously treated with standard therapy for their underlying malignancy. Part B (CLOVER-WaM) is a pivotal efficacy study evaluating IV administration of iopofosine I 131 in patients with WM that have received at least two prior lines of therapy.

Key facts

Study ID

NCT02952508

Run by

Cellectar Biosciences, Inc.

People needed

120

Starts

2017-07-26

Expected to finish

2027-12-22

Last updated by the study team

2026-03-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Cellectar Biosciences site — Redlands, California, United States
• Cellectar Biosciences site — Washington D.C., District of Columbia, United States
• Cellectar Biosciences site — Jacksonville, Florida, United States
• Cellectar Biosciences site — Miami, Florida, United States
• Cellectar Biosciences site — Tampa, Florida, United States
• Cellectar Biosciences — Atlanta, Georgia, United States
• Cellectar Biosciences site — Maywood, Illinois, United States
• Cellectar Biosciences site — Warrenville, Illinois, United States
• Cellectar Biosciences site — Westwood, Kansas, United States
• Cellectar Biosciences site — New Orleans, Louisiana, United States
• Cellectar Biosciences site — Baltimore, Maryland, United States
• Cellectar Biosciences — Bethesda, Maryland, United States
• Cellectar Biosciences site — Boston, Massachusetts, United States
• Cellectar Biosciences — North Bergen, New Jersey, United States
• Cellectar Biosciences site — Buffalo, New York, United States
• Cellectar Biosciences site — New York, New York, United States
• Cellectar Biosciences site — Rochester, New York, United States
• Cellectar Biosciences site — Durham, North Carolina, United States
• Cellectar Biosciences — Canton, Ohio, United States
• Cellectar Biosciences site — Cincinnati, Ohio, United States
• Cellectar Biosciences Site — Charleston, South Carolina, United States
• Cellectar Biosciences — Greenville, South Carolina, United States
• Cellectar Biosciences site — Knoxville, Tennessee, United States
• Cellectar Biosciences site — Dallas, Texas, United States
• Cellectar Biosciences site — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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