Expressions of TRPV1 in Airway of Asthmatics

Withdrawn before enrolling · Not applicable

Conditions studied: Moderate Persistent Asthma, Severe Persistent Asthma, Nodule Solitary Pulmonary, Pulmonary Atelectasis

In brief

The purpose of this study is to measure the density of a temperature-sensitive protein, named TRPV1, in the airway mucosa tissue of both non-asthmatic and moderate to severe persistent asthmatic patients. This study may generate information for developing new therapeutic strategy.

Key facts

Study ID

NCT02952066

Run by

Lu Yuan Lee

People needed

0

Starts

2017-09-20

Expected to finish

2018-11-20

Last updated by the study team

2021-06-14

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Competent to understand informed consent
• Diagnosis of moderate to severe persistent allergic asthma.
• Clinical need for diagnostic bronchoscopy for assessment of asthmatic symptoms (e.g., to assess presence of chronic infection with non-tuberculous mycobacteria or other infectious agents as a cause for lack of asthma control) or therapeutic bronchoscopy for management of asthmatic symptoms (e.g., thermoplasty).
• Asthmatic subjects with history of positive skin test to confirm presence of allergy.
• Asthmatic subjects with pre-albuterol forced expiratory volume in the first second (FEV1) of <70% of the predicted value.
• Non-asthmatic patients will include those patients with solitary pulmonary nodules and healthy individuals with acute lung atelectasis (e.g. airway blocked by mucus plugs or foreign object).
• Scheduled for a diagnostic or therapeutic bronchoscopy procedure.

You may not qualify if…

• Inability to perform pulmonary function testing
• Unstable asthma control for asthmatic subjects
• An asthma exacerbation within the past month
• History of intubation for asthma
• History of smoking
• History of prematurity
• History of any lung disease or disorder except asthma
• History of congenital or acquired heart disease
• Pregnant/lactating females
• Any serious concurrent systemic disease including but not limited to diabetes, coronary artery disease, vasculitis, etc.
• History of heart arrhythmias including supraventricular tachycardia

Where it is running

• University of Kentucky Medical Center — Lexington, Kentucky, United States

Full record on ClinicalTrials.gov

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