The Effects of Nicotinamide Adenine Dinucleotide (NAD) on Brain Function and Cognition
Completed · Not applicable · Has a placebo group
Conditions studied: Mild Cognitive Impairment, NAD
In brief
The purpose of this study is to determine the effects of Niagen (nicotinamide riboside, vitamin B3), on NAD levels, brain function including cognition and blood flow in people diagnosed with mild cognitive impairment (MCI).
Key facts
- Study ID
- NCT02942888
- Run by
- The University of Texas Health Science Center at San Antonio
- People needed
- 46
- Starts
- 2017-11-30
- Expected to finish
- 2021-08-16
- Last updated by the study team
- 2021-09-02
Who can join
Age: 65 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Previously diagnosed with MCI based on inclusion criteria of Texas Alzheimer's Research Care and Consortium (TARCC) study (IRB: HSC20090535H). We are enrolling both genders, all races and ethnic groups.
- Two week washout period for participants who were taking opioids or a dose of niacin over 200mg
You may not qualify if…
- Previously considered as healthy individuals without a MCI or Alzheimer's disease diagnosis based on exclusion criteria of the TARCC study (IRB: HSC20090535H).
- Neurological, psychiatric or active systemic medical disease
- Diabetes
- Moderate or severe depression and/or anxiety as determined the Geriatric Depression Scale (GDS) and the Geriatric Anxiety Scale (GAS), respectively
- Diagnosis of dementia
- Hearing, vision, motor or language deficits
- Alcohol or drug abuse
- Implantation of metal devices
- Administration of Alzheimer's drugs, anticholinergics, neuroleptics, anticonvulsants, opiates, systemic steroids, and mood-stabilizers.
- No opioid use while participating in study
Where it is running
- South Texas Veterans Healthcare System (STVHCS) — San Antonio, Texas, United States
- University of Texas Health San Antonio — San Antonio, Texas, United States
Full record on ClinicalTrials.gov
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