Antigen Presentation and Lymphocyte Response in Parkinson's Disease

Completed

Conditions studied: Parkinson's Disease

In brief

The way the immune system responds to certain PD-related proteins in PD donors compared to the way it responds in persons without or fewer PD related proteins is not well studied and this study aims to analyze the autoimmune response in each group. The study involves a one time visit involving brief questionnaires and a blood draw of 30 mL (approximately 2 tablespoons) to be collected.

Key facts

Study ID

NCT02939534

Run by

Columbia University

People needed

95

Starts

2015-02-01

Expected to finish

2021-02-01

Last updated by the study team

2021-02-21

Who can join

Age: 50 and older, up to 90. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Moderate to advanced PD with classic motor features, and must demonstrate two of the following three: rest tremor, rigidity, or bradykinesia
• Dopaminergic medication benefit (self-reported improvement)
• Age at recruitment: 50 - 90 years
• Age at diagnosis > 47
• PD duration > 3 years
• Willingness to have genotyping and genetic studies as part of laboratory research

You may not qualify if…

• Atypical parkinsonism or other neurological disorders
• Recent history of cancer (past 3 years)
• Autoimmune disease (except thyroid disease)
• On chronic immune-modulatory therapy (e.g. SIT (specific immunotherapy), anti-IgE)
• Inability to provide informed consent

Where it is running

• University of California San Diego School of Medicine — La Jolla, California, United States
• Shirley Ryan Ability Lab — Chicago, Illinois, United States
• Columbia University Medical Center — New York, New York, United States

Full record on ClinicalTrials.gov

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