Can the Memory Support Intervention Improve Depression Outcome Following Cognitive Therapy?

Completed · Not applicable

Conditions studied: Depressive Disorder, Major

In brief

The aim of this study protocol is to conduct a confirmatory efficacy trial to test whether the Memory Support Intervention improves illness course and functional outcomes in major depressive disorder (MDD) and cognitive therapy (CT).

Key facts

Study ID

NCT02938559

Run by

University of California, Berkeley

People needed

178

Starts

2016-11-01

Expected to finish

2020-08-05

Last updated by the study team

2021-02-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 18+ years
• Willing and able to give full consent
• English language fluency
• Diagnosis of major depressive disorder (MDD), first episode, recurrent or chronic, according to DSM-5
• Minimum score 26 or above on the Inventory of Depressive Symptomatology, Self-Report (IDS-SR). This cutoff denotes at least 'moderate' depression
• If taking medications for mood, medications must be stable for the past four weeks

You may not qualify if…

• History of Bipolar Disorder
• History of Psychosis or psychotic features
• Lifetime history of failure to respond to 4 or more sessions of CBT/CT for depression
• Current non-psychotic disorder if it constitutes the principal diagnosis and if it requires treatment other than that offered in the project. 'Principal' is defined as the disorder currently most distressing and disabling, using a widely accepted severity rating scale capturing distress and interference (0-8, 4+ indicates clinical severity)
• Moderate or severe substance use in the past 6 months where 'moderate' is defined as 4-5 symptoms and 'severe' is defined as 6+ listed in DSM-5 for each of the substance-related disorders
• Evidence of any medical disorder or condition that could cause depression, preclude participation in CT, or is associated with memory problems, that is not currently stabilized and/or managed under the care of a physician or the presence of an active and progressive physical illness or neurological degenerative disease,
• Current suicide risk sufficient to preclude treatment on an outpatient basis (assessed by the Columbia-Suicide Severity Rating Scale) or current homicide risk (assessed by our staff, a case manager or psychiatrist)
• Pregnancy or breastfeeding
• Not able/willing to participate in and/or complete the pre-treatment assessments

Where it is running

• University of California, Berkeley — Berkeley, California, United States

Full record on ClinicalTrials.gov

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