Graded TTCE for Post-Embolization PAVM Monitoring

Completed

Conditions studied: Hereditary Hemorrhagic Telangiectasia (HHT)

In brief

Current HHT guidelines recommend CT scan to detect new or recurrent PAVMs after embolotherapy. Recent studies using transthoracic contrast echocardiography (TTCE) shunt grade for PAVM screening suggest that graded TTCE can accurately predict the size of PAVMs on chest CT and their amenability to embolization. This study's purpose is to evaluate whether TTCE shunt grade can also accurately predict PAVM size and amenability to treatment in patients who are post-embolization.

Key facts

Study ID

NCT02936349

Run by

University of Pennsylvania

People needed

32

Starts

2016-10-01

Expected to finish

2019-11-01

Last updated by the study team

2019-11-08

Who can join

Age: 18 and older, up to 89. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age range 18-89 years old
• Diagnosis of Hereditary Hemorrhagic Telangiectasia by the Curacao criteria
• Prior diagnosis of one or more PAVMs treated by embolotherapy
• Chest CT performed within the Penn system for surveillance of PAVMs after \\ embolotherapy

You may not qualify if…

• Known PAVM recurrence on most recent chest CT with feeding artery size amenable to repeat embolotherapy
• Known history of intracardiac shunt
• Discovery of intracardiac shunt during transthoracic contrast echocardiography

Where it is running

• Hospital of the University of Pennsylvania — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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