Investigating the Stability, Variability and Mechanism of Incorporation of Lipid Mediators Into Eccrine Sweat

Completed · Not applicable

Conditions studied: Stability & Variability of Lipid-derived Molecules in Sweat

In brief

The purpose of this study is to see what the differences are in sweat (amount and small molecule content) collected from different sites of the body and by different methods of sweat stimulation. Additionally, the investigators want to know whether the amount and small molecule content of the sweat is the same in an individual over time, and the same across individuals at a given time. Finally, the investigators want to know how consumption of over-the-counter anti-inflammatory drugs such as ibuprofen will affect the inflammatory mediator content of sweat and how that compares to blood. This information will help to better understand the composition and behavior of sweat and assess its potential utility as a routine clinical tool in skin research.

Key facts

Study ID

NCT02935894

Run by

USDA, Western Human Nutrition Research Center

People needed

14

Starts

2016-11-28

Expected to finish

2017-06-08

Last updated by the study team

2018-06-01

Who can join

Age: 20 and older, up to 40. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• 20-40 y
• Male
• Weight > 110 pounds

You may not qualify if…

• Diagnosed active chronic diseases for which the individual is currently taking daily medication, including but not limited to:
• Diabetes mellitus
• Cardiovascular disease
• Cancer
• Gastrointestinal disorders
• Kidney disease
• Liver disease
• Bleeding disorders
• Asthma
• Autoimmune disorders
• Hypertension
• Osteoporosis
• Recent minor surgery (within 4 wk) or major surgery (within 16 wk)
• Recent antibiotic therapy (within 4 wk)
• Recent hospitalization (within 4 wk)
• Use of over-the-counter or prescription medications at the time of the study that directly affect endpoints of interest (e.g. hyperlipidemia, glycemic control, steroids, statins, anti-inflammatory agents, and weight loss aids)
• Adults who are not able to consent
• Under current medical supervision
• Ibuprofen intolerance or allergy
• Those with a bleeding disorder
• Current enrollee in a clinical research study.
• Individuals with blood clotting or platelet defect disorders
• Individuals with orthopedic limitations or cardiovascular risk that preclude participation in the physiological stimulation of sweat by light exercise portion of the study
• Individuals who are trained athletes or that regularly perform physical activity defined as "vigorous" by the Centers for Disease Control and Prevention

Where it is running

• Western Human Nutrition Research Center — Davis, California, United States

Full record on ClinicalTrials.gov

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