Burst Suppression Anesthesia for Treatment of Severe Depression

Completed · Phase 1

Conditions studied: Major Depressive Disorder

In brief

This study is designed to determine if the antidepressant effects of deep anesthesia via propofol are related to EEG burst suppression.

Key facts

Study ID

NCT02935647

Run by

University of Utah

People needed

11

Starts

2016-10-01

Expected to finish

2018-09-01

Last updated by the study team

2021-06-02

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• • Diagnosis of Major Depressive Disorder (MDD) or bipolar Disorder (I or II, most recent episode must be depression
• Failed at least 2 anti-depressant treatments and no ECT in past 6 months
• Age between 18-55 years
• BMI < 35
• Hamilton Rating Scale for Depression (HSRD) score > 18
• Quick Inventory of Depression Scale (QIDS) score > 10.

You may not qualify if…

• • Diagnosis of primary psychotic disorder, dysthymia, or personality disorder
• Significant pre-morbid cognitive impairment
• Hypertension and current use of ACE inhibitor or AR blocker medications
• Symptomatic coronary artery disease or congestive heart failure
• History of transient ischemic or neurologic signs during the past year
• History of or susceptibility to malignant hyperthermia
• Contraindication to isoflurane or propofol anesthesia (as determined by anesthesiologist)
• Diabetes requiring insulin
• Poor kidney function
• Chronic use of benzodiazepines or opioids
• Individuals incompetent to provide consent (e.g. catatonic, psychotic).

Where it is running

• University Neuropsychiatric Institute — Salt Lake City, Utah, United States

Full record on ClinicalTrials.gov

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