Effects of Behavioral Interventions on Mechanisms of Pain Regulation and Hedonic Regulation

Stopped early · Not applicable

Conditions studied: Chronic, Non-neuropathic Back Pain

In brief

The overarching aim of this project is to conduct a randomized controlled study to determine whether Mindfulness-Oriented Recovery Enhancement (MORE) vs. a Support Group (SG) can improve pain regulation and hedonic functions (i.e., natural reward responsiveness) thought to be governed by the endogenous opioid system among opioid-treated, chronic, non-neuropathic back pain patients (CNBP) and thereby improve clinical pain, affect, and opioid use.

Key facts

Study ID

NCT02935465

Run by

University of Utah

People needed

17

Starts

2016-09-01

Expected to finish

2019-06-01

Last updated by the study team

2020-03-06

Who can join

Age: 21 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• age 21-60 years of age
• English fluency
• 20/20 vision with corrective lenses
• current chronic, non-neuropathic back pain diagnosis determined by physician assessment
• reporting pain ≥3 on 0-10 scale with opioid medication
• current use of prescription opioids for ≥3 consecutive months
• ability to understand study procedures and to comply with them for the entire length of the study

You may not qualify if…

• Mindfulness experience (e.g., MBSR or shamatha/vipassana meditation)
• psychosis
• untreated, active suicidality in the past month
• and severe non-opioid substance use disorder in the past year as assessed with the MINI
• clinically unstable illness judged to interfere with treatment, and presence of facial/jaw pain
• pregnancy
• inability or unwillingness of individual to give written informed consent
• physical characteristics that preclude neuroimaging or study procedures (e.g., metal implants, etc.

Where it is running

• College of Social Work — Salt Lake City, Utah, United States

Full record on ClinicalTrials.gov

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