Dental Malocclusion and Craniofacial Development in OI

Running, not enrolling

Conditions studied: Osteogenesis Imperfecta

In brief

Osteogenesis imperfecta (OI) is a rare inherited disorder that causes bones to break easily. Individuals with osteogenesis imperfecta break bones often and may have other problems, including hearing loss and pain and difficulty getting around. People with moderate to severe OI may also be diagnosed with dentinogenesis imperfecta (DI). DI is characterized by grey or brown teeth that may chip and wear down and break easily. People with DI may also have skull and neck defects. These patients may have severe teeth misalignment resulting in clinically significant chewing problems. Teeth misalignment in OI is very hard to treat because of the quality and quantity of bone. The overall goal of this study is to improve dental health to improve the quality of life of people with OI.

Key facts

Study ID

NCT02934451

Run by

Baylor College of Medicine

People needed

75

Starts

2016-08-01

Expected to finish

2027-12-01

Last updated by the study team

2026-01-27

Who can join

Age: 10 and older, up to 100. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Males and females with Clinical diagnosis of OI other than OI type I
• Individuals 10 years or older
• Participant of the Brittle Bone Disease (BBD) Longitudinal Study (7701)

You may not qualify if…

• Individuals who cannot be correctly positioned for valid radiographic analysis (e.g., due to severe scoliosis or short neck secondary to basilar invagination)
• Women who are pregnant

Where it is running

• University of California Los Angeles — Los Angeles, California, United States
• Baylor College of Medicine — Houston, Texas, United States
• Shriners Hospital for Children — Montreal, Quebec, Canada

Full record on ClinicalTrials.gov

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