Assessment of Satiety Following Oral Administration of an Erythritol Sweetened Beverage
Completed · Not applicable
Conditions studied: Satiety in Healthy Volunteers
In brief
Erythritol is a low calorie sugar substitute that is being increasingly used to sweeten beverages and other food items. Greater amounts of erythritol are required to reach the sweetness level of a common soft drink as compared to aspartame, resulting in higher osmolarity for the erythritol sweetened beverage. Since associations have been noted between osmolarity and satiety, investigators propose that an erythritol sweetened beverage may enhance satiety more than a beverage sweetened with aspartame.
Key facts
- Study ID
- NCT02934321
- Run by
- University of Florida
- People needed
- 12
- Starts
- 2017-09-18
- Expected to finish
- 2019-08-23
- Last updated by the study team
- 2019-08-28
Who can join
Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy
- BMI below 25
- Maintained a stable body weight for at least three months prior to volunteering
You may not qualify if…
- Exclude if smoking, substance abuse, have a chronic medical or psychiatric illness, regularly intake medications (except for oral contraceptives), regularly use supplements besides vitamins/minerals, have a history of gastrointestinal or renal disorders, have food allergies, have medical dietary restrictions, or have any abnormalities detected on physical examination indicative of disease.
- Participants must have intact gastrointestinal and kidney function to adequately absorb and eliminate the erythritol. Eligibility will be determined by self-reported medical history, physical examination, and specific questioning to exclude prior renal or Gastrointestinal disease after the informed consent process.
- Exclude if abnormal GI anatomy due to surgery (besides appendix removal) or congenital defect as may impair ghrelin production.
- Exclude if the patient is pregnant, lactating, or planning to become pregnant as erythritol has not been specifically tested in this population.
- Exclude if have a Body Mass Index over 25, as ghrelin as a marker of satiety may not be accurate at high Body Mass Index.
Where it is running
- University of Florida Clinical Research Center — Gainesville, Florida, United States
Full record on ClinicalTrials.gov
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