Low VW Activity in Adolescent HMB

Status unconfirmed

Conditions studied: Von Willebrand Factor Deficiency

In brief

This is a research study for patients diagnosed with heavy menstrual bleeding (HMB) and low Von Willebrand Factor (VWF). Menstruation, also known as a period, is the regular discharge of blood and tissues from the uterus. HMB is having a heavier amount of discharge during menstrual period. Low Von Willebrand Factor means that the participant has lower level of a blood protein that is important for clotting of blood and so, the participant is at a higher risk for bleeding. The purpose of this project is to study the genetic differences of adolescent females with HMB and low VWF activity and compare the genetic differences with their bleeding manifestations, response to medications and outcome.

Key facts

Study ID

NCT02933411

Run by

Baylor College of Medicine

People needed

120

Starts

2017-01-05

Expected to finish

2025-11-01

Last updated by the study team

2022-04-11

Who can join

Age: any, up to 21. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Post-menarchal females less than 21 years of age
• HMB defined as PBAC score greater than 100
• VWF:Activity more than or equal to 30 and less than or equal to 50 IU/dL x 2
• VWF: Activity /VWF:Ag ratio greater than or equal to 0.6
• Normal VW multimers, if performed

You may not qualify if…

• Post menarchal females age greater than or equal to 21 years
• VWF: Activity less than 30 or greater than 50 IU/dL consistently, type 2 or type 3 VWD
• Presence of other bleeding disorders (thrombocytopenia, platelet function defect, coagulation factor deficiency, fibrinogen defect or deficiency)

Where it is running

• Children's Hospital of Atlanta — Atlanta, Georgia, United States
• Michigan State University — East Lansing, Michigan, United States
• Children's Mercy Hospital — Kansas City, Missouri, United States
• Joseph M Sanzari Children's Hospital — Hackensack, New Jersey, United States
• Hemophilia Center of Western New York — Buffalo, New York, United States
• Mary M. Gooley Hemophilia Center — Rochester, New York, United States
• Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States
• Nationwide Children's Hospital — Columbus, Ohio, United States
• University of Pittsburgh — Pittsburgh, Pennsylvania, United States
• Vanderbilt University Medical Center — Nashville, Tennessee, United States
• University of Texas Southwestern Medical Center- Children's Medical Center — Dallas, Texas, United States
• Texas Children's Hospital — Houston, Texas, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.