Cognitive Remediation for Alcohol Use Disorder and Posttraumatic Stress Disorder

Completed · Not applicable · Has a placebo group

Conditions studied: Alcohol Use Disorder, PTSD, Cognitive Dysfunction

In brief

The project will examine whether a computerized neuroscience-based cognitive training program can improve cognitive functioning and recovery outcomes among Veterans with Alcohol Use Disorder and co-occurring PTSD. Information from this study will help determine the malleability of cognitive dysfunction, an established risk factor for poor recovery outcomes in this population. Improved functional outcomes can decrease risk of chronic impairment and ultimately help affected individuals live richer, more productive lives. Web-based treatment technologies may increase the reach and impact of treatment, and foster patient recovery in cases where staffing, space, acceptability of counseling, and transportation are barriers. Findings may also support expanding use of existing, highly-accessible cognitive remediation technologies to other vulnerable clinical populations.

Key facts

Study ID

NCT02929979

Run by

VA Office of Research and Development

People needed

90

Starts

2015-01-01

Expected to finish

2019-07-21

Last updated by the study team

2021-02-11

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Be a Veteran
• Meet DSM-5 diagnostic criteria for current AUD
• Meet DSM-5 criteria for current PTSD
• Be willing to perform daily home-based computer exercises for 6 weeks

You may not qualify if…

• Individuals will be excluded based on evidence of the following:
• History of, or current, psychotic disorder or Schizophrenia
• Current scheduled (i.e., daily) prescribed use of cognitive enhancers (e.g., Memantine) or stimulants (e.g., Methylphenidate) that may enhance cognitive performance
• Current severe traumatic brain injury (DoD TBI Screen 2)
• Any type of dementia (Mini Mental Status Exam (MMSE) < 24), delirium or medical illnesses associated with potential cognitive issues (HIV, Hypothyroidism, B-12 deficiency)
• Any level of mental retardation (Wechsler Test of Adult Reading WTAR)
• Limited ability to speak/read/write/understand English (WTAR)
• Inadequate vision or hearing
• Active suicidal/homicidal intent
• Self-report and collateral history from medical record/primary care physician/outpatient addiction treatment team will be used as necessary to determine inclusion and exclusion.
• Suicidal and homicidal intent will be assessed in the context of a structured clinical interview.
• In the unlikely event that respondents endorse active intent they will be referred immediately for treatment and will be excluded from the current study.

Where it is running

• VA Palo Alto Health Care System, Palo Alto, CA — Palo Alto, California, United States

Full record on ClinicalTrials.gov

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