Atropine in Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)

Completed · Not applicable

Conditions studied: Catecholaminergic Polymorphic Ventricular Tachycardia

In brief

To test the hypothesis that increasing the sinus node rate with atropine treatment prior to exercise will reduce exercise-triggered ventricular ectopy compared to baseline in patients with CPVT.

Key facts

Study ID

NCT02927223

Run by

Vanderbilt University

People needed

6

Starts

2016-10-01

Expected to finish

2019-02-01

Last updated by the study team

2020-01-28

Who can join

Age: 6 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age >/= 6 years
• Able to provide written informed consent
• Clinical diagnosis of CPVT
• Able to exercise on a treadmill
• Successful completion of a minimum of 2 exercise stress tests without adverse events

You may not qualify if…

• Contraindication to treadmill stress testing according to Vanderbilt University Medical Center's clinical protocols (unstable angina, decompensated congestive heart failure, severe hypertension (≥ 170/90 mmHg), acute myocardial infarction (<4 days), moderate to severe aortic stenosis, acute pulmonary embolism, severe pulmonary hypertension, outflow tract obstruction, hypertrophic cardiomyopathy, left main coronary stenosis, left bundle branch block)
• Females who are pregnant
• In the judgement of the investigator, any clinically significant ongoing medical or surgical condition that might jeopardize the subject's safety or interfere with the conduct of the study

Where it is running

• Vanderbilt University — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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