Study of Proton Versus Photon Beam Radiotherapy in the Treatment of Head and Neck Cancer

Running, not enrolling · Phase 2

Conditions studied: Head and Neck Cancer

In brief

Compared to IMRT, PBRT is thought to give less radiation exposure to the surrounding healthy tissues. It is possible that side effect rates with PBRT will be lower or the same compared to IMRT, but this has not been well studied to date. Although both of these radiation therapies have been used in the past to treat head and neck cancer, this research study will compare the effects of these two different radiation treatment modalities with each other to see whether PBRT is better, the same or worse than IMRT.

Key facts

Study ID

NCT02923570

Run by

Memorial Sloan Kettering Cancer Center

People needed

108

Starts

2016-10-03

Expected to finish

2026-10-01

Last updated by the study team

2025-11-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age greater than or equal to 18.
• Histopathologically confirmed diagnosis of one the following cancer types:
• Salivary gland cancer
• Skin cancer
• Melanoma
• HNSCC that require ipsilateral radiation
• Patients must be a candidate for ipsilateral radiation therapy.
• Karnofsky performance status ≥70.
• Negative pregnancy test for women of childbearing potential (<51 years of age) as per institutional policy.

You may not qualify if…

• Any prior head or neck irradiation.
• Physician recommendation of bilateral neck radiation.
• Non-resectable disease
• Physician recommendation of mucosal radiation

Where it is running

• Baptist Alliance MCI — Miami, Florida, United States
• Mayo Clinic — Rochester, Minnesota, United States
• Memorial Sloan Kettering Basking Ridge — Basking Ridge, New Jersey, United States
• Memorial Sloan Kettering Monmouth — Middletown, New Jersey, United States
• Memorial Sloan Kettering Bergen — Montvale, New Jersey, United States
• Memorial Sloan Kettering Commack — Commack, New York, United States
• Memorial Sloan Kettering Westchester — Harrison, New York, United States
• Memorial Sloan Kettering Cancer Center — New York, New York, United States
• Memorial Sloan Kettering Nassau — Uniondale, New York, United States

Full record on ClinicalTrials.gov

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